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. 2017 Jun 5;11(8):1078–1098. doi: 10.1002/1878-0261.12076

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© 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Sequential dovitinib/TMZ treatment increases toxicity. We performed sequential treatment with Dov and TMZ. (A) Schematic representation of the sequential treatment strategy over 7 days using Dov (5 μm) and TMZ (100 μm) in GB‐10 and U251. WST assays were performed to determine the percentage cell viability of (B) GB‐10 and (C) U251 after pretreatment with 5 μm Dov for 3 days, followed by 3 days with 100 μm TMZ and 1 day of 5 μm Dov. No treatment controls (NT) and single TMZ or Dov treatment controls were employed. Graphs show SEM from three independent experiments; ***P < 0.001; **P < 0.01; *P < 0.05.