Table 1.

Univariate associations of various putative predictor variables with in-hospital mortality in TTP patients who underwent TPE. (Using the Nationwide Inpatient Sample 2007–2012).

	All patients*		In-hospital Deaths*
	# of subjects	%	# of subjects	%	Odds Ratio	Lower 95% CI	Upper 95% CI	P-value
All TTP patients who underwent TPE	8203*	100.00	613*	100.00
DEMOGRAPHICS
Age Categories
Children (<18 years old)	109	1.3	**	**	1.47	0.19	11.42	0.63
18–44 years age (reference)	3629	44.2	115	15.89	1
44–59 years old	2616	31.9	160	39.25	2.05	1.19	3.53	<0.01
60 years and above	1849	22.5	333	44.0	6.78	4.15	11.08	<0.0001
GENDER
Male	2686	32.8	203	33.6	1
Female	5507	67.2	410	66.4	0.94	0.61	1.45	0.78
RACE***
African-American (reference)	2840	47.2	303	27.0	1
Caucasian.	3164	38.8	134	62.0	2.15	1.35	3.44	<0.01
Others****	948	14.0	56	11.0	1.22	0.59	2.51	0.58
IN-HOSPITAL COMPLICATIONS
CNS Bleed	89	1.1	27	4.3	6.83	2.29	20.39	<.001
Non Central Nervous Bleeding.	936	11.4	110	17.9	1.70	0.98	2.94	0.06
Arterial Thrombosis	35	0.4	15	2.5	13.47	2.68	67.61	<0.001
Acute Myocardial Infarction (AMI)	463	5.6	103	16.7	3.61	1.97	6.61	<.0001
Ischemic Stroke	460	5.6	96	15.6	3.67	2.00	6.74	<.0001
PROCEDURES
Platelet Transfusion	791	9.6	120	19.6	2.45	1.52	3.96	<0.001
RBC Transfusion	3284	40.0	332	54.2	1.87	1.30	2.70	<0.001
COMORBIDITIES
Renal Failure	4432	54.0	494	80.6	3.88	2.46	6.13	<.0001
Diabetes	1154	16.1	67	12.7	0.77	0.43	1.37	0.37
Obesity	903	12.6	54	10.2	0.78	0.41	1.49	0.46
Hypertension	3694	51.6	278	53.0	1.07	0.72	1.59	0.72
Systemic Lupus Erythematosus	391	4.8	35.2	5.7	1.21	0.54	2.69	0.64

^*Subjects included in these analyses are defined as those with the ICD-9-CM discharge code of TTP who underwent TPE.

^**Data values <10 and not shown per HCUP guidelines.

^***Race has missing data on 15.4% (n=257) of the TTP subjects who underwent TPE

^****Other races include: Hispanic, Asian or Pacific Islanders, Native Americans and other minority races.