Reduced connectivity between left inferior parietal lobe (IPL) (blue) and the first cluster: (A) the right angular gyrus (AG); the right superior temporal gyrus (STG); the right supramarginal gyrus (SmG), and the insular cortex (IC) (p < 0.001); the second cluster (B) right dorsal posterior cingulate cortex (dpCC) and left and right somatosensory association cortices (SsAC) (p < 0.001); the third cluster: the left dpCC, the left SsAC, the left retrosplenial cingulate cortex (RsCC), and the left cingulate cortex (CC) (p < 0.03); (C) after the Mediterranean diet and physical activity program compared to baseline. Data are thresholded at a voxel-wise threshold of p ≤ 0.05 and a cluster-extent threshold of p ≤ 0.05, FWE-corrected and FDR-corrected.