Table 3.
The performance of the pLDH ELISA, malaria antibody ELISA, and the RDT for the detection of malaria parasites, as compared with the microscopic method (GM)
| Parameter | pLDH ELISA % (CI) | Antibody ELISA % (CI) | RDT % (CI) |
|---|---|---|---|
| Sensitivity | 86.0 (77.4 – 92.8) | 69.9 (60.1 – 78.6) | 88.0 (80.0 – 94.0) |
| Specificity | 92.7 (85.6 – 97.0) | 80.3 (69.9 – 88.3) | 99.1 (98.0 – 99.3) |
| PPV | 91.6 (83.4 – 96.5) | 81.8 (72.2 – 89.2) | 89.8 (78.0 – 92.3) |
| NPV | 88.1 (80.2 – 93.7) | 67.7 (57.4 – 76.9) | 99.0 (98.2 – 99.5) |
| FPR | 7.3 (5.8 – 9.1) | 19.7 (17.3 – 22.3) | 1.2 (0.6 – 2.1) |
| FNR | 2.3 (1.5 – 3.4) | 30.1 (27.3 – 33.1) | 12 (6.4 – 20.0) |
| Agreement between tests | 89.7 (84.4 – 93.7) | 74.5 (67.5 – 80.6) | 97.9 (96.9 – 98.6) |
Sensitivity = [true positive/(true positive + false negative) × 100]; specificity = [true negative/(true negative + false positive) × 100; PPV = [true positive/(true positive + false positive) × 100]; NPV = [true negative/(true negative + false negative) × 100]; Agreement = [true positive + true negative/N × 100]; FPR = 1 ˗ specificity; FNR = 1 ˗ sensitivity