Table I.

Cohort characteristics by HIV Serostatus and Cocaine use

	HIV− (n =147)		HIV+ (r)=194)		p valuec
	Controls (n=94)	Cocainea (n=53)	Controls (n=112)	Cocainea (n=82)	HIV− controls vs. HIV− cocaine	HIV+ controls vs. HIV+ cocaine
Baseline Age (years; mean, SD)	41.8 (7.0)	39.8 (6.3)	39.0 (5.4)	39.1 (4.8)	ns	ns
Follow-up (years; mean, SD)	5.9 (3.1)	6.1 (2.5)	6.6 (3.7)	6.5 (3.3)	ns	ns
Demographic and Clinical Characteristics (%)
Race					ns	ns
Black	79.8	67.9	72.3	70.7
White, non-Hispanic	18.1	20.8	21.4	22.0
Other	2.1	11.3	6.3	7.3
Education < 12 years	40.4	45.3	47.3	42.7	ns	ns
HCV-antibody positive	20.2	32.1	21.4	18.3	ns	ns
Heavy Smokinga	25.0	50.9	17.7	52.4	<0.01	<0.01
Heavy Drinkinga	19.1	47.2	18.1	42.7	<0.01	<0.01
Depression Profile
Antidepressant usea	16.0	26.4	18.8	50.0	ns	<0.01
CES-D score > 16b	23.4	37.7	26.8	46.3	ns	<0.01
HIV-Related Characteristics (%)
Baseline CD4 count (cells/mm3)
< 200	–	–	17.0	15.9	–	ns
< 350	–	–	33.0	30.5		ns
Baseline viral load (plasma HIV RNA, copies/mL)
> 400	–	–	56.3	63.4	–	0.02
Self-reported antiretroviral therapy use
Baseline	–	–	64.3	58.5	–	ns
> 95% of visits in study	–	–	42.0	26.8	–	<0.01

^a- Reported heavy use at ≥ 2 visits in study (corresponding to at least one year); Cocaine use defined as daily or weekly; Smoking defined as ≥ ½ pack cigarettes/day; Drinking defined as >14 alcoholic drinks/week

^b- Reported at > 50% of visits in study

^c- Wilcoxon rank sum or paired t-test; p<0.05, significant

Abbreviations: CES-D, Center for Epidemiologic Studies Depression Scale; ns, nonsignificant; SD, standard deviation; HCV, Hepatitis C Virus.