Fig 3. Glucose consumption and lactate release are elevated by meclizine under normoxic and hypoxic conditions.
(A) Meclizine increases glucose consumption in DRG cultures. Following incubation under normoxic or hypoxic conditions, glucose concentration in medium is depleted to a greater extent in cultures supplemented with meclizine. (B) Extracellular lactate levels are elevated by meclizine under normoxic or hypoxic conditions. Simultaneous addition of 2DG abrogates meclizine effects. Data are presented as mean±SEM for 4 independent experiments. *indicates different from normoxia; ** indicates different from hypoxia; P<0.05.