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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2016 Jul 22;99:20–31. doi: 10.1016/j.freeradbiomed.2016.07.022

Fig 4. During hypoxia, meclizine preserves NADPH levels via glycolytic metabolism.

Fig 4

Hypoxia increases NADP+ (A) and decreases NADPH (B) in DRG neurons. NADP+/NADPH ratio (C) which increases 3-fold in hypoxia is maintained at near normoxic value in the presence of meclizine. Concomitant addition of 2DG (diagonal lines) abrogates this effect. Values are given as mean±SEM for 4 independent experiments; *indicates difference between hypoxia −/+ meclizine or between hypoxia with meclizine in the presence of 2DG; P< 0.05.