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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Free Radic Biol Med. 2016 Jul 22;99:20–31. doi: 10.1016/j.freeradbiomed.2016.07.022

Fig 7. Glycolysis is indispensable for meclizine-mediated prevention of ATP depletion by hypoxia.

Fig 7

In normoxia ATP, content is not altered by meclizine (red), but is reduced by ~25% by 50 mM 2DG. Following hypoxia ATP content decreases by ~50%. Meclizine supplementation partially prevents ATP decrease (red), but the effect is abrogated by simultaneous addition of 2DG. ATP amounts are expressed in nmol/mg protein and presented as mean±SEM of six independent experiments; *indicates different from normoxia; **indicates different from hypoxia +/− 2DG; P<0.05.