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. 2017 Jul 4;7(7):e1168. doi: 10.1038/tp.2017.139

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Increased expression of NRG1 in the mPFC of fear-conditioned mice. (a) There were no significant differences in pain threshold. (b) Conditioned mice, but not unpaired controls, showed fear responses 24 h after training. (c, d) NRG1 levels in the mPFC are enhanced in FC mice. (e, f) Total ErbB4 levels did not change between the control and FC groups. FC, fear-conditioned; mPFC, medial prefrontal cortex; NRG1, Neuregulin-1.