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. 2017 Jul 4;7(7):e1168. doi: 10.1038/tp.2017.139

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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ErbB4 expressed in the PL cortex is required for fear expression. (a–d) Infusion of the ErbB4 antagonist (AG1478) into the PL cortex decreased fear expression (d), but no significant differences were observed in pain thresholds (a), fear training (b), immediate freezing behaviors (c) or pre-tone freezing behaviors (d). n=6 for each group. (e, f) The western blot images show the successful knockdown of the ErbB4 protein in the PL cortex. (g–j) Both the AAV-Cre-injected mice and AAV-GFP-injected mice showed comparable pain thresholds (g), fear training (h), immediate freezing behaviors (i) and pre-tone freezing behaviors (j). AAV-Cre-injected mice showed impaired fear expression (j). n=12 for each group. Data are presented as the means±s.e.m. *P<0.05, **P<0.01, ***P<0.001, two-tailed t-test. AAV, adeno-associated virus; GFP, green fluorescent protein; PL, prelimbic.