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. 2017 Jul 4;7(7):e1168. doi: 10.1038/tp.2017.139

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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ErbB4 expressed in PV-positive neurons is required for fear expression. (a) Costaining of PV in tdTomato-expressing neurons. Sections were prepared from adult ErbB4-2A-CreERT2;Ai14 mice and stained for PV (green). Scale bar, 50 μm. (b–e) Pain thresholds (b), fear training (c), immediate freezing behaviors (d) and pre-tone freezing behaviors (e) were not different in the control (n=12) and PV-Cre;ErbB4^−/− mice (n=13). PV-Cre;ErbB4^−/− mice (n=11) showed impaired fear expression (e). (f–i) CaMKII-Cre;ErbB4^−/− mice showed normal pain thresholds (f), fear learning (g), immediate freezing behaviors (h), pre-tone freezing behaviors (i) and fear expression (i) compared with the controls (n=12). Data are presented as the means±s.e.m. *P<0.05, **P<0.01, ***P<0.001, two-tailed t-test. PV, parvalbumin.