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. 2017 Jul 4;7(7):e1168. doi: 10.1038/tp.2017.139

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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ErbB4 overexpression in the PL cortex rescues the deficits in PV-Cre;ErbB4^−/− mice. (a, b) The western blot images show the successful overexpression of the ErbB4 protein in the PL region. (c–f) LV-ErbB4 expressed within the PL cortex rescued the fear memory deficits in PV-Cre;ErbB4^−/− mice (f). No differences were observed in pain thresholds (c), fear learning (d), immediate freezing behaviors (e) or pre-tone freezing behaviors (f). n=12 for each group. Data are presented as the means±s.e.m. *P<0.05, **P<0.01, ***P<0.001, two-tailed t-test. PL, prelimbic; PV, parvalbumin.