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. 2017 Jul 25;7(7):e1176. doi: 10.1038/tp.2017.152

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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The systemic alterations resulting in the changes in free fatty acids (FFA) patterns in schizophrenia patients. Insufficient energy supply in the brains of schizophrenia patients causes excess lipolysis and β-oxidation, accompanied by FFA and ROS accumulation. Additional oxidative stress caused by active β-oxidation and other factors results in lipid peroxidation, causing loss of polyunsaturated fatty acids (PUFAs) from the lipid membrane. The increased FFAs increase the risk of metabolic diseases such as cardiovascular diseases and type II diabetes in schizophrenia patients.