Fig 2.

Major clinical outcomes among patients with PSC over time. Shown are proportions of patients who experience PSC-related death, liver transplant, deaths from cholangiocarcinoma, deaths from colorectal carcinoma, and other deaths through four sequential time periods. PSC related liver failure was the leading cause of death prior to 1990s but has been largely supplanted by liver transplant (4, 5, 9, 33, 40-49). (Outcomes are charted according to the year they were published)

* PSC-related deaths include liver failure (most common), pancreatic/hepatic malignancy, esophageal varices, liver abscess/ sepsis, fulminant colitis.