Skip to main content
. Author manuscript; available in PMC: 2018 May 18.
Published in final edited form as: Cell. 2017 May 18;169(5):930–944.e22. doi: 10.1016/j.cell.2017.05.004

Figure 2. CTCF is required for accumulating loops between CTCF/Cohesin binding sites.

Figure 2

(A-B) Snapshots of 1.3 Mb of Hi-C data at 20kb resolution CTCF-AID mESCs aligned with CTCF ChIP-seq and the Smc1a HiChIP loops identified by Mumbach et al. 2016. Normalized Hi-C counts are multiplied by 105

(C) Genome-wide aggregation of normalized Hi-C signal anchored at Smc1a HiChip loops separated by 280 to 380kb (1196 loops). Similar results were obtained for smaller and larger loops. See Figure S2