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. Author manuscript; available in PMC: 2018 May 18.
Published in final edited form as: Cell. 2017 May 18;169(5):930–944.e22. doi: 10.1016/j.cell.2017.05.004

Figure 4. Proper insulation of TADs is not required for higher-order segregation of A and B compartments.

Figure 4

(A) Hi-C contact maps at 100kb resolution across entire chromosome 2. Bar denotes segments called as A (green) or B (red) compartment using 20kb-cis Eigenvector 1. Normalized Hi-C counts are multiplied by 105

(B) Distributions of cis Eigenvector 1 values across entire chromosome 2 are remarkably stable to depletion of CTCF

(C) cis Eigenvector 1 values are not affected genome-wide by CTCF depletion

(D) Overall scaling of Hi-C contact frequency as a function of genomic distance is not affect by the loss of CTCF, highlighting that CTCF does not affect general chromatin compaction. See Figure S4