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. Author manuscript; available in PMC: 2018 May 18.
Published in final edited form as: Cell. 2017 May 18;169(5):930–944.e22. doi: 10.1016/j.cell.2017.05.004

Figure 7. CTCF does not constrain H3K27me3 spreading in mESCs and summary model.

Figure 7

(A) A subset of CTCF binding sites mark transitions in H3K27me3 patterns

(B-C) CTCF depletion does not trigger H3K27me3 spreading beyond the formerly bound CTCF site itself (center)

(D) Our observations are consistent with TAD formation by loop extrusion, and establish CTCF as the major factor defining domain boundaries genome-wide

(E) Statistical average cartoon representation of TAD disruption and compartment preservation upon loss of CTCF

See Figure S7.