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. 2001 Jul 24;98(16):9116–9121. doi: 10.1073/pnas.161284298

Figure 3.

Figure 3

Forced expression of ChREBP activates expression from the LPK promoter in response to glucose in vivo. Primary hepatocytes were cotransfected with 0.5 μg of the luciferase reporter construct driven by the LPK promoter and 1.5 μg of the ChREBP cDNA under the control of the constitutively active cytomegalovirus (CMV) promoter (filled bars) or with the empty expression vector (open bars). After transfection, the cells were incubated for 12 h in medium containing 10 mM lactate, 5.5 mM glucose, or 27.5 mM glucose. Values represent the mean ± standard error of five experiments.