Rate constants for pharmacokinetic modeling of liposomal doxorubicin. The first order rate constants for modeling pharmacokinetic behavior of liposomal doxorubicin in mice. All values are in h−1. The elimination rate constant, kel, and the rate constants that describe movement between the vascular and peripheral compartments, kp and kd, are determined with fits to data obtained in tumor-free mice. These are then held constant to model data from LS 174T tumor-bearing mice to determine values for the rate constant to describe movement into the tumor compartment from the circulation and back, kepr and kb, respectively.