Table 1.

Rate constants for pharmacokinetic modeling of liposomal doxorubicin. The first order rate constants for modeling pharmacokinetic behavior of liposomal doxorubicin in mice. All values are in h⁻¹. The elimination rate constant, k_el, and the rate constants that describe movement between the vascular and peripheral compartments, k_p and k_d, are determined with fits to data obtained in tumor-free mice. These are then held constant to model data from LS 174T tumor-bearing mice to determine values for the rate constant to describe movement into the tumor compartment from the circulation and back, k_epr and k_b, respectively.

Rate Constant	Tumor-free (s−1)	LS 174T tumor (s−1)
kp	14.0
kd	19.9
kel	0.1	0.124
kepr		0.011
kb		0.022