Figure 1.

Antibody titers to Borrelia burgdorferi by sonicate IgM (A) or IgG (B) ELISA are shown for patients with erythema migrans (acute and convalescent [Conv] phase), acute-phase neurologic or cardiac involvement (Acute neuro carditis), arthritis or late neurologic abnormalities (Arthritis late neuro), and post-infection symptoms (Post Lyme disease). The antibody titers were plotted on a logarithmic scale. For IgG determinations, a titer of >1 :400 was defined as positive, a titer of 1:200 or 1:400 was defined as indeterminate, and a titer <1:100 was defined as negative. For IgM determinations, a titer>1:200 was defined as positive, a titer 1:100 was defined as indeterminate, and a titer <1:100 was defined as negative. The absorbance values with an ELISA that employs a 26-mer peptide from the sixth invariant region (C6) of the variable major protein-like sequence-expressed (VlsE) lipoprotein of the spirochete are shown for the same patient groups (C). The absorbance values are plotted on an arithmetic scale. In all 3 panels, the horizontal bars indicate mean values for patients with positive responses, vertical bars indicate 1 SD, stipled areas indicate indeterminate range, and cross-hatched areas indicate negative range.