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. 2017 Jun 13;58(8):1536–1547. doi: 10.1194/jlr.M073270

Fig. 2.

Fig. 2.

AMPK activation increases the protein expression of ABCA1 and ABCG1 in peritoneal macrophages of apoE−/− mice. Peritoneal macrophages were prepared from apoE−/− mice fed a high-fat diet (containing 1.2% cholesterol and 10% lard) and treated with vehicle, A-769662 (30 mg/kg, ip), AICAR (200 mg/kg, ip), metformin (260 mg/kg, by gavage), or IMM-H007 (200 mg/kg, by gavage) for 10 weeks. The protein expression of pT172-AMPK (A), AMPK (B), ABCA1 (C), ABCG1 (D), SR-BI (E), and LXR-α (F) in peritoneal macrophages was determined by Western blot. Data are mean ± SEM for n = 5 per group. *P < 0.05, **P < 0.01 versus control.