Fig. 1.

Combination treatment with GPR40 and GPR120 agonists in diabetic db/db mice provided better glycemic control than either monotherapy. A: Body weight changes. B: Nonfasting blood glucose changes. C: Insulin tolerance test (ITT) glucose. D: Glucose AUC (0–120 min) during ITT. Data are mean ± SEM. Combo, MK-2305 at 10 mpk and Cpd A at 30 mpk were codosed (n = 8); GPR40, GPR40 selective agonist MK-2305 dosed at 10 mpk (n = 8); GPR120, GPR120 selective agonist Cpd A dosed at 30 mpk (n = 8); Rosi, Rosi dosed at 3 mpk (n = 8); vehicle, 0.5% methylcellulose (n = 8). One-way ANOVA test. * P < 0.05, ** P < 0.01, *** P < 0.001.