TABLE 1.
Genotype | TC | FC | CE | PL | FFA | BA |
WT (6) | 159.8 ± 22.9 | 27.5 ± 1.3 | 132.3 ± 22.9 | 85.6 ± 2.4 | 86.6 ± 5.6a | 21.8 ± 9.1a |
Cd36−/− (6) | 159.8 ± 10.4 | 31.0 ± 4.8 | 128.8 ± 10.9 | 92.5 ± 5.0 | 85.0 ± 4.9a | 27.1 ± 15.1a |
L-Fabp−/− (5) | 147.5 ± 11.6 | 24.0 ± 3.7 | 123.6 ± 12.3 | 95.8 ± 4.6 | 80.7 ± 9.1a | 19.6 ± 4.1a |
DKO (6) | 159.4 ± 24.9 | 32.4 ± 1.9 | 127.0 ± 26.7 | 93.9 ± 2.7 | 132.9 ± 10.9b | 33.2 ± 11.2a |
Mice from four experimental groups (n per group) were fed a LD for 4 weeks. Hepatic lipids were extracted and analyzed (Materials and Methods). Hepatic lipid content is expressed as mean ± SE (µg/mg protein), except FFA (nmol/mg protein). The difference between values associated with different superscript letters for the parameters indicated in each vertical column is statistically significant (P < 0.05). BA, bile acid; CE, cholesteryl ester; FC, free cholesterol; FFA, free fatty acid; PL, phospholipid; TC, total cholesterol.