TABLE 2.

Biliary lipid secretion in LD-fed mice of the indicated genotype

Genotype	TC	PL	BA	Flow rate
WT (12)	210.5 ± 6.9a	646.7 ± 14.9a	5103.8 ± 233.7a	91.6 ± 1.2
Cd36−/− (7)	175.1 ± 8.6a	603.3 ± 24.1a	4827.9 ± 302.6a	89.3 ± 1.7
L-Fabp−/− (9)	298.3 ± 11.9b	985.6 ± 39.9b	6907.5 ± 426.3b	115.9 ± 4.5
DKO (4)	221.8 ± 8.8ab	819.7 ± 31.9a	3900.1 ± 589.3a	83.2 ± 0.7

Mice from four experimental groups (n per group) were fed a LD for 2 weeks. Bile samples were collected after surgical laparotomy for 1 h. Biliary cholesterol (TC), phospholipids (PLs), and bile acids (BAs) were analyzed (Materials and Methods). Biliary lipid secretion is expressed as nmol/min/kg bw. Flow rate is expressed as µl/min/kg bw. The difference between values associated with different superscript letters for the parameters indicated in each vertical column is statistically significant (P < 0.05).