Table 1.
Demographics, risk factors, and presentation of vascular graft infections.
Cases | ||||||
---|---|---|---|---|---|---|
| ||||||
1 | 2 | 3 | 4 | 5 | 6 | |
Gender | Female | Male | Female | Male | Female | Male |
Age | 68 | 60 | 70 | 67 | 72 | 68 |
Infected prosthetic graft | Aortobifemoral bypass graft | Aorto-SMA graft | Femoral–femoral bypass | Jump graft from left limb of ABF to profunda | Right external iliac artery-SFA bypass | Right axillary-bifemoral bypass |
Graft type | Dacron | Dacron, propaten | Bovine pericardial patch and PTFE | Dacron | Dacron | Dacron and bovine pericardial patch |
Infection location | Intra-abdominal and bilateral groins | Intra-abdominal | Right groin | Left groin | Right groin | Right groin |
Prior graft revisions | ||||||
Total | 1 | 4 | 7 | 5 | 2 | 4 |
3 months prior | 0 | 2 | 3 | 2 | 2 | 4 |
1 month prior | 0 | 1 | 1 | 2 | 0 | 4 |
Time to infection | 11 years | 2.5 months | 1 month | 10 days | 2 months | 3 weeks |
Other infection risk factors | Gangrenous cholecystitis Bowel ischemia |
Urostomy Multiple recent femoral revisions |
Multiple open thrombectomies of prior fem-pop bypass | Colostomy midline abscess ex-lap for SBO | Aortoenteric fistula Thrombectomy of RLE 24 h after ax-fem |
|
Signs and symptoms | Abdominal and back pain No fevers, leukocytosis, or bacteremia |
Abdominal pain, sepsis, leukocytosis, lactic acidosis, bowel ischemia | Fevers and chills, erythema and purulent drainage from right groin | Left groin erythema and purulent drainage No fevers, leukocytosis, or bacteremia |
Right groin erythema and pain No fevers, leukocyteosis, or bacteremia |
Right groin erythema and purulent drainage No fevers, leukocytosis, or bacteremia |
Diagnosis | CT scan: fluid collection at all anastomoses | Ex lap: thrombosed graft with purulence | CT scan: fluid surrounding R femoral artery/fem–fem anastomosis | Clinical exam | CT scan: fluid collection surrounding bypass graft | CT scan: fluid and air around right femoral anastomosis |
Initial antibiotics | Vancomycin aztreonam metronidazole | Tigecycline aztreonam metronidazole | Vancomycin rifampin | Piperacillin-tazobactam | Vancomycin piperacillin-tazobactam | Vancomycin piperacillin-tazobactam |
Cultures | Wound: no growth | Wound: VRE, Pseudomonas | Wound: MRSA Blood: MRSA |
Wound: Serratia, Candida albicans | Wound: S. epidermidis | Wound: VRE, E. coli, |
Graft management plan | Explant with in situ reconstruction | Explant with in situ reconstruction | Explant with extra-anatomic bypass | Graft preservation (no further extra-anatomic options) | Graft preservation (metastatic ovarian CA) | Graft preservation (no further extra-anatomic options, unable to tolerate further bypass) |
SMA: superior mesenteric artery; VRE: vancomycin-resistant Enterococci faecalis; MRSA: methicillin-resistant Staphylococcus aureus; CT: computed tomopgraphy; SBO: small bowel obstruction.