Table 2.
Incubation periods of the Fukuoka-1 (FU-1) prion strain in transgenic mice
| Inoculum | Host | Incubation period (days)a | n/n0b |
|---|---|---|---|
| RML brain homogenate | Tg(MoPrP)4053 | 51 ± 3c | 8/8 |
| Tg(Mo/HuPrP)1014/Prnp0/0 | 107 ± 5c | 4/4 | |
| CJD brain homogenate | Tg(Mo/HuPrP)1014/Prnp0/0 | 78 ± 1c | 7/7 |
| Tg(HuPrP)2669/Prnp0/0 | 143 ± 2c | 9/9 | |
| RML/N2a cell lysate | Tg(MoPrP)4053 | 77 ± 3 | 8/8 |
| Tg(Mo/HuPrP)1014/Prnp0/0 | 154 ± 1 | 8/8 | |
| FU-1/N2a cell lysate | Tg(MoPrP)4053 | 103 ± 2 | 8/8 |
| Tg(Mo/HuPrP)1014/Prnp0/0 | 103 ± 4 | 8/8 | |
| Tg(HuPrP)2669/Prnp0/0 | >500 | 0/8 | |
| FU-1/N2a cell lysate →Tg(MoPrP)4053 | Tg(MoPrP)4053 | 76 ± 0 | 8/8 |
| Tg(Mo/HuPrP)1014/Prnp0/0 | 82 ± 2 | 7/7 | |
| Tg(HuPrP)2669/Prnp0/0 | >500 | 0/6 | |
| FU-1/N2a cell lysate →Tg(Mo/HuPrP)1014 | Tg(MoPrP)4053 | 120 ± 10 | 8/8 |
| Tg(Mo/HuPrP)1014/Prnp0/0 | 95 ± 2 | 8/8 | |
| Tg(HuPrP)2669/Prnp0/0 | >500 | 0/6 |
aData reported as mean ± standard error of the mean.
bn, number of mice showing clinical signs of disease; n0, number of mice inoculated.
cData previously reported in Berry et al. (2013).