Skip to main content
. 2017 Jun 1;9(8):1150–1164. doi: 10.15252/emmm.201707604

Figure 5. GDF15 is a bona fide heart‐derived hormone that regulates liver GH signaling.

Figure 5

  • A
    Design of AAV9‐mGDF15 shRNA construct to specifically knockdown GDF15 in Cre+ cardiomyocytes.
  • B–G
    Cardiac Gdf15 expression quantified by qPCR (B), plasma GDF15 concentrations measured by ELISA (C), cardiac Bnp expression quantified by qPCR (D), liver phosphorylated STAT5 level measured by ELISA (E), and plasma IGF1 (F) and GH concentrations (G) measured by ELISA in 9‐ to 10‐day‐old littermate control and αKOγKO mice (n = 8–12 mice per group) that received pericardial injection of AAV9‐control or Gdf15 shRNA at 2 days of age. *P < 0.05, **P < 0.01, and ***P < 0.001 by t‐test. Values are mean + s.e.m.