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. 2017 Jun 12;9(8):1030–1051. doi: 10.15252/emmm.201607088

Figure EV3. Knockdown of autophagy inducer LC3 inhibits cisplatin‐mediated cell death in HPV(+) HNSCC cells.

Figure EV3

  • A, B
    siRNA‐mediated knockdown of LC3B was confirmed using Western blotting with anti‐LC3B antibody compared to Scr‐siRNA‐transfected controls (A). Actin was used as a loading control, and blots are representative of three independent experiments. Effects of siRNA‐mediated knockdown of LC3B on cisplatin‐mediated cell death were measured, and IC50 concentrations were calculated by MTT assays (B) compared to Scr‐siRNA‐transfected controls (48 h). Data are means ± SD from three independent experiments, analyzed by unpaired Student's t‐test (*P < 0.05).