Figure EV4. HPV‐E7 enhances mitochondrial ceramide‐dependent lethal mitophagy.

1. Effects of siRNA‐mediated knockdown of HPVE6/E7 on UM‐SCC‐47 growth inhibition in response to C₁₈‐pyr‐cer (72 h) or vehicle (DMSO) were measured by MTT assay. Scr‐siRNA‐transfected cells were used as controls. Data are means ± SD from three independent experiments, analyzed by unpaired Student's t‐test (*P < 0.05).
2. Effects of ectopic expression of HPV‐E6 versus HPV‐E7 on HPV(−) UM‐SCC‐22A growth inhibition in response to C₁₈‐pyr‐cer (72 h) or vehicle (DMSO) were measured by MTT assay. Vector‐transfected cells were used as controls. Data are means ± SD from three independent experiments, analyzed by unpaired Student's t‐test (*P < 0.05).