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. 2017 Jun 1;31(11):1073–1088. doi: 10.1101/gad.298232.117

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© 2017 Riera et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 2. — Origin recognition. (A) The domain and structural organization of Orc and Cdc6 proteins. The initiator-specific motif region of the AAA-RecA domain is indicated in red. (B, left) The OCCM structure in top view and side view (Protein Data Bank [PDB]: 5UDB). (Right) A top view of the ORC/Cdc6–DNA structure is shown enlarged. (C) Archaeal Orc (PDB: 2V1U) and the DNA-binding subunits of S. cerevisiae (Sc) ORC and Cdc6 are shown (PDB: 5UDB). The DNA-binding regions are indicated by red circles. The Orc4 insertion helix is shown in dark blue. (D) An overlay of S. cerevisiae Orc4 (PDB: 5UDB), D. melanogaster (Dm) Orc4 (PDB: 4XGC), and H. sapiens (Hs) Orc4 (PDB: 5UJM). (E) Structural comparison of D. melanogaster Orc1–Orc2 with S. cerevisiae Orc1–Orc2. The arrows show the rotation of D. melanogaster Orc1 AAA⁺ and Orc2 WHD to fit the S. cerevisiae Orc1 AAA⁺ and Orc2 WHD positions.