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. 2017 Jun 1;31(11):1147–1161. doi: 10.1101/gad.299420.117

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© 2017 Peter et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — The interactions between the canonical and noncanonical sequences of GYF2 and 4E-BP1 with 4EHP. (A,B) Close-up views of the interactions between the 4EHP dorsal surface and the GYF2 and 4E-BP1 canonical helices. 4E-BP1 residue R63 is colored in dark blue after its Cγ atom and is highlighted with a black dashed box. The corresponding residues in GYF2 (F52) are also highlighted by a black dashed box. (C,D) Close-up views of the interaction between the 4EHP lateral surface and the GYF2 and 4E-BP1 noncanonical linkers. (E,F) Close-up views of the interactions between the 4EHP lateral surface and the GYF2 and 4E-BP1 noncanonical loops. Selected interface residues are shown as sticks. For clarity, all residues labeled with an asterisk are shown without their side chain.