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Mutation frequencies in bMMRD cancers with subsequent mutations in Pol epsilon or Pol delta. Data for seven exomes of bMMRD cancer (five mutated Pol epsilon and two mutated Pol delta). Relative frequencies of single-nucleotide substitutions are shown irrespective of the strand; data from TCGA database for MMR-deficient (MSI) and MMR-proficient (MSS) samples without mutations in Pol epsilon and Pol delta are shown for comparison. N is the number of mutations observed in each sample.
