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Canonical (left) and alternative (right) NF-κB pathway and the target strategies: (1) inhibition of cell-surface receptor binding, (2) inhibition of receptor adaptor proteins, (3) IKK inhibition, (4) blocking IκB degradation/upregulating IκB /inhibiting proteasome, (5) inhibit nuclear translocation, and (6) block DNA binding/transcriptional activation.
