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. Author manuscript; available in PMC: 2018 Aug 28.
Published in final edited form as: Cancer Lett. 2017 Jun 7;402:177–189. doi: 10.1016/j.canlet.2017.05.028

Figure 2. Akt1 deficiency increases apoptosis and inhibits proliferation in TRAMP mouse prostate.

Figure 2

(A) Representative images of 12 and 31 week old prostate tissue sections from TRAMP/Akt1+/+, TRAMP/Akt1+/−, TRAMP/Akt1−/− mice showing TUNEL and Ki67 staining (n=6). (B) Bar graphs showing quantification of the TUNEL positive cells in 12 and 31 week old TRAMP/Akt1−/− and TRAMP/Akt1+/− mice prostates compared to TRAMP/Akt1+/+ (n=6). (C) Bar graphs showing the number of Ki67 positive cells in 12 and 31 week old TRAMP/Akt1−/− and TRAMP/Akt1+/− mice prostates compared to TRAMP/Akt1+/+ (n=6). (D) Representative Western blot images and (E) bar graphs showing expression levels of Akt1, cleaved caspase-3, cleaved caspase-8 and β-actin in 31 week old TRAMP/Akt1+/+, TRAMP/Akt1+/−, TRAMP/Akt1−/− mice prostate tissue lysates (n=4). Data presented as Mean ± SD; *P < 0.05.