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According to our data cellular amyloid formation consists of six steps: (1) Uptake of SAA1 protein into the cells, (2) intracellular fibril nucleation, (3) leakage of intracellular compartments, (4) formation of cellular clusters, (5) release of intracellular SAA1 into the extracellular space and (6) further extracellular growth of the nucleated deposit.
