Skip to main content
. 2017 Aug 1;12(8):e0181692. doi: 10.1371/journal.pone.0181692

Fig 3. Trajectories of DLCO of patients with various clinical characteristics, using the linear mixed model with random effect.

Fig 3

Panel A. Patients with presence or history of digital ulcers (DU) had a significantly higher baseline DLCO% but a faster decline of DLCO than patients without presence or history of digital ulcers (no DU) in multivariate analysis: -2.45±0.45 vs -1.01±0.33%/year (p = 0.01). Panel B. Patients with a right heart catheterization-proven precapillary pulmonary hypertension at baseline or during follow-up (PH) had a similar baseline DLCO% but a faster decline of DLCO than patients without a right heart catheterization-proven precapillary pulmonary hypertension at baseline or during follow-up (no PH) in multivariate analysis: -2.37±0.55 vs -1.19±0.31%/year (p = 0.049). Panel C. Patients with a limited ILD according to Goh et al. had a significantly higher baseline DLCO than patients with an extensive ILD but the slope of decrease in DLCO was similar in both groups (-1.69±0.33 vs -0.90±0.53%/year (p = 0.21). Panel D. Patients with a limited cutaneous SSc (lcSSc) had similar baseline DLCO and slope of decrease in DLCO than patients with diffuse SSc (dSSc) (p = 0.40 and p = 0.93, respectively).