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. 2017 Jul 27;12:5359–5372. doi: 10.2147/IJN.S139039

Figure 1.

Figure 1

Structure analysis of marker-MNPs.

Notes: (A) Structural diagram of naked nanobeads. (B) Structural diagram of marker-MNPs. Red fonts indicate restriction sites of FAPα. (C) Fluorescence spectra of marker-MNPs conjugated with fluorescein-labeled peptides and naked beads incubated with an equivalent amount of free fluorescein-labeled peptides (excitation: 492 nm; emission: 500–700 nm; quenching efficiency =90.8%). (D) Fluorescent image of fluorescence quenching. (E) Average fluorescence of marker-MNPs incubated in 10% mouse serum at 37°C over time (excitation: 492 nm; emission: 518 nm). (F) Average fluorescence of marker-MNPs incubated in urine of mice at 37°C over time.

Abbreviations: MNPs, magnetic iron oxide nanoparticles; RFU, relative fluorescence unit.