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Schematic and design of the approach.
Notes: Marker-MNPs composed of nanobeads conjugated with an FAPα-sensitive substrate in tandem with a ligand-encoded reporter. These agents survey the vasculature for the sites where FAPα cleaves and releases the reporters into urine for analysis by ELISA.
Abbreviations: ELISA, enzyme-linked immunosorbent assay; FAPα, fibroblast activation protein α; MNPs, magnetic iron oxide nanoparticles.
