Figure 5.

Urinary diagnosis of solid tumor by marker-MNPs.

Notes: Two doses, that is, (A–C) 100 nM and (E–G) 10 nM of marker-MNPs were co-injected with the reporter control into Eca109 tumor-bearing mice and healthy control mice and urinary reporters (R or Rc) were measured by ELISA. (D, H) ROC curve was plotted to distinguish ESCC tumor mice from healthy mice.

Abbreviations: ROC, receiver-operating characteristic; ELISA, enzyme-linked immunosorbent assay; ESCC, esophageal squamous cell carcinoma; MNPs, magnetic iron oxide nanoparticles.