Table 4.
Genotype frequencies and calculated ORs for the Asp299Gly (A wild-type allele, G risk mutant allele) and the Thr399Ile (C wild-type allele, T risk mutant allele) SNPs in the TLR4 gene
| SNP | Genotype | AMD =0 | AMD =1 | OR (95% CI) | P-value | AIC |
|---|---|---|---|---|---|---|
| 299 | A/A | 100 (97.1%) | 106 (88.3%) | 1.00 | 0.01 | 305.2 |
| A/G | 3 (2.9%) | 14 (11.7%) | 4.40 (1.23–15.78) | |||
| 399 | C/C | 101 (98.1%) | 108 (90%) | 1.00 | 0.0088 | 305 |
| C/T | 2 (1.9%) | 12 (10%) | 5.61 (1.23–25.68) |
Notes: Bold values indicate statistically significant correlations. AMD =0 indicates the healthy control population and AMD =1 indicates the AMD patients.
Abbreviations: AIC, Akaike information criterion; AMD, age-related macular degeneration; CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism.