Table 6.
Multivariate model of AMD risk based on genotypes and clinical and environmental factors
| Variables in the equation
| ||||||||
|---|---|---|---|---|---|---|---|---|
| Variables | B | SE | Wald | df | P-value | OR | 95% CI
|
|
| Lower | Upper | |||||||
| TLR_299 | 0.879 | 0.807 | 1.185 | 1 | 0.276 | 2.408 | 0.495 | 11.715 |
| TLR_399 | 0.996 | 0.930 | 1.145 | 1 | 0.285 | 2.706 | 0.437 | 16.757 |
| ARMS2 | 0.882 | 0.302 | 8.528 | 1 | 0.003* | 2.417 | 1.337 | 4.370 |
| Smoking | 0.605 | 0.335 | 3.253 | 1 | 0.071 | 1.830 | 0.949 | 3.531 |
| Cataract | −0.495 | 0.357 | 1.927 | 1 | 0.165 | 0.609 | 0.303 | 1.226 |
| Glaucoma | −1.125 | 0.513 | 4.815 | 1 | 0.028* | 0.325 | 0.119 | 0.887 |
| Hypertension | 0.148 | 0.403 | 0.135 | 1 | 0.714 | 1.159 | 0.526 | 2.555 |
| Diabetes | −0.902 | 0.346 | 6.790 | 1 | 0.009* | 0.406 | 0.206 | 0.800 |
| Heart disease | −0.339 | 0.402 | 0.711 | 1 | 0.399 | 0.712 | 0.324 | 1.567 |
| Constant | −2.819 | 1.116 | 6.383 | 1 | 0.012 | 0.060 | ||
Notes:
*
Statistically significant. Bold values indicate statistically significant correlations.
Abbreviations: AMD, age-related macular degeneration; B, coefficient of the parameter to be analyzed in the logistic regression model; SE, standard error; Wald, Wald statistic; OR, odds ratio; CI, confidence interval.