Fig 1. Inhibitive effect of immediate perfusion of DHB on hERG currents.

(A) Examples of current traces in control and DHB-treated groups were recorded using illustrated voltage clamp protocol. (B) Normalized I–V relationships for tail current with and without various concentrations of DHB (1, 10 and 100 μM). DHB significantly decreased hERG current. *P < 0.05, **P < 0.01 vs. control, n = 10. (C) Half-maximal inhibitory concentration (IC50) of DHB against hERG current (n = 10).