Fig 7. DHB disrupts interactions between hERG and chaperones.
(A) Western blot analysis of Hsp70 and Hsp90 after 24 h incubation with 1 μM and 10 μM DHB. Hsp90 expression was concentration-dependently reduced while Hsp70 expression did not change. *P < 0.05 vs. control, n = 4. (B) Immunoprecipitation results show increased and decreased interaction between hERG and Hsp70 or Hsp90 respectively after treatment with 10 μM DHB. *P < 0.05 vs. control, n = 3.