Table 1. A total of 24 genes were down-regulated by RORγt siRNAs or inverse agonists in human Th17 cells.
The change in gene expression resulted from treatment of RORγt siRNAs or RORγt inverse agonists was presented in fold change of the geomean average calculated from samples of the two donors.
| Gene | Down-regulated by RORγt siRNAs | Down-regulated by RORγt inverse agonists | GeoMean Fold Change by RORγt siRNAs | GeoMean Fold Change by RORγt inverse agonists |
|---|---|---|---|---|
| ABCA1 | Yes | -1.3 | -1.3 | |
| ADAM12 | Yes | -1.4 | -1.5 | |
| C2CD4A | Yes | Yes | -1.6 | -1.7 |
| C2CD4B | Yes | -1.7 | -1.8 | |
| CCL20 | Yes | Yes | -1.4 | -1.8 |
| CCR6 | Yes | -1.4 | -1.9 | |
| COL5A1 | Yes | -1.2 | -1.7 | |
| COL5A3 | Yes | Yes | -1.6 | -1.9 |
| CTSH | Yes | Yes | -1.6 | -1.7 |
| GNLY | Yes | -1.7 | -1.3 | |
| IL17A | Yes | Yes | -3.4 | -4.3 |
| IL17F | Yes | Yes | -1.9 | -2.0 |
| IL22 | Yes | Yes | -1.6 | -2.0 |
| IL26 | Yes | -1.7 | -1.6 | |
| IQCG | Yes | -1.5 | -1.5 | |
| MATN2 | Yes | -1.0 | -2.5 | |
| NOL3 | Yes | -1.1 | -1.2 | |
| PKHD1 | Yes | -2.8 | -3.6 | |
| PPARG | Yes | -1.0 | -1.3 | |
| PXDC1 | Yes | Yes | -1.8 | -2.3 |
| RAPGEF3 | Yes | -1.4 | -1.9 | |
| RORC | Yes | -1.9 | -1.2 | |
| SH3D21 | Yes | -1.1 | -1.3 | |
| TIMP1 | Yes | -1.2 | -1.6 |