Table 3. Top 10 canonical pathways in IPA associated with the 24 genes that were down-regulated by RORγt siRNAs or inverse agonists in human Th17 cells.
The top 10 canonical pathways were selected by the p-value of overlap of the 24 genes and the genes in each pathway.
| Ingenuity Canonical Pathways | -log(p-value) | Involved Genes |
|---|---|---|
| Role of Cytokines in Mediating Communication between Immune Cells | 6.24 | IL26,IL22,IL17F,IL17A |
| T Helper Cell Differentiation | 4.03 | RORC,IL17F,IL17A |
| IL-17 Signaling | 4.01 | TIMP1,IL17F,IL17A |
| Role of IL-17A in Psoriasis | 3.94 | CCL20,IL17A |
| Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F | 3.65 | IL17F,IL17A |
| Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F | 3.43 | IL17F,IL17A |
| IL-17A Signaling in Gastric Cells | 3.36 | CCL20,IL17A |
| Inhibition of Matrix Metalloproteases | 2.97 | ADAM12,TIMP1 |
| Hepatic Fibrosis / Hepatic Stellate Cell Activation | 2.83 | COL5A1,COL5A3,TIMP1 |
| Role of IL-17A in Arthritis | 2.69 | CCL20,IL17A |