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. 2017 Jul 14;36(15):2182–2183. doi: 10.15252/embj.201797621

Figure 1. Interaction between the C2 domain of Notch ligands and the phospholipid membrane modulates Notch signaling.

Figure 1

The interaction between Notch receptors in one cell (blue) and Notch ligands (Jagged‐1, purple; Jagged‐2, green; Delta‐like‐4, brown) in the neighboring cell is mediated by the EGF11‐13 domain in the Notch receptor and EGF1/DSL/C2 domains in the Notch ligands. Previous work showed that the receptor–ligand affinity varies between Notch ligands and is regulated by fucosylation of the Notch‐interacting domain (horizontal arrows). The work by Suckling et al (2017) shows evidence that Notch–ligand interaction can also be modulated by the contact between the ligand C2 domain and the phospholipids in the cell membrane that displays Notch (vertical dashed arrows). The variability in the structure between the C2 domains of the different ligands may affect its interaction with membranes containing different lipid compositions.