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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Cell Rep. 2017 Apr 25;19(4):719–732. doi: 10.1016/j.celrep.2017.04.013

Figure 3. High titers of autologous and heterologous neutralization achieved in guinea pigs.

Figure 3

(A) Immunization scheme for guinea pigs. Week 18 sera were used for neutralization assays.

(B) Neutralization of wild type and 4-glycan-deleted viruses by week 18 sera of guinea pigs immunized with fully glycosylated and glycan-deleted immunogens. Immunogenicity is expressed as log10(ID50) with respect to autologous and heterologous strains for each immunogen. The standard error for individual animals is displayed following the “±” sign. WT, wild type virus; ΔGly4, 4-glycan-deleted virus.

(C) Targeted glycan-removal increases sensitivity of 4-glycan-deleted viruses to antibodies targeting the CD4 supersite.

See also Figure S4 and Table S3, S4.

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