Fig. 3.

IMCL accumulation in type 1 fibers inversely correlates with insulin sensitivity. A shows a significant correlation between the decline in insulin sensitivity and increasing area stained by IMCL within type 1 fibers (LAI). B shows a similar finding. Here, the decline in insulin sensitivity correlates inversely with change in area stained by IMCL after adjustment for percent distribution of type 1 fibers (adjusted LAI). Only data from the University of Pittsburgh (n = 26) is presented, as the crossover study design (lipid vs. glycerol infusion) enabled the direct comparison of IMCL accumulation on insulin sensitivity within the same subject. GIR, glucose infusion rate.