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(a) Representative trace of normalized eEPSC amplitude under fasting (red) and feeding (blue). 100 µM IEM-1640, competitive Cp-AMPARs blocker, was applied to bath solution at 10–25 min. 10 µM CNQX, AMPARs blocker, was also applied to bath solution at 20–25 min. (b) Average normalized eEPSC amplitude onto POMC neurons under fed condition was decreased by IEM 1460 but not under fasted condition.
