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. 2017 Apr 13;313(1):G80–G87. doi: 10.1152/ajpgi.00448.2016

Fig. 5.

Fig. 5.

5-HT3 receptor antagonist inhibits 5-HT-evoked ΔIsc only in GF mice whereas 5-HT4 receptor antagonist significantly blocks ΔIsc in both HM and GF mice. A: change in short-circuit current in response to cumulative concentration of 5-HT and 5-HT in the presence of ondansetron in GF mice. B: change in short-circuit current in response to cumulative concentration of 5-HT and 5-HT in the presence of ondansetron in HM mice. C: change in short-circuit current in response to cumulative concentration of 5-HT and 5-HT in the presence of ondansetron in CR mice. D: change in short-circuit current in response to cumulative concentration of 5-HT and 5-HT in the presence of GR-113808 in GF mice. E: change in short-circuit current in response to cumulative concentration of 5-HT and 5-HT in the presence of GR-113808 in HM mice. F: change in short-circuit current in response to cumulative concentration of 5-HT and 5-HT in the presence of GR-113808 in CR mice. 5-HT-induced Emax for GF (G), HM (H), and CR (I) mice in the presence of ondansetron (Ond) and GR-113808 (GR). *P < 0.05.